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2015-09-14T12:00:32+03:00
2015-09-14T14:15:22+08:00
2015-09-14T14:17:02+08:00
Acrobat PDFMaker 11 Word 版
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Construction of Energy-Optimal Smooth Monophasic Defibrillation Pulse Waveforms Using Cardiomyocyte Membrane Model
The goal is to help create smooth energy-optimal monophasic pulse waveforms for defibrillation using the Luo-Rudy cardiomyocyte membrane computer model. The waveforms were described with the help of the piecewise linear function. Each line segment provides a transition from one present level of the transmembrane potential to the next with a minimal energy value. The duration of the last segment was defined as a minimum duration at which an action potential occurs. Monophasic waveforms of segments 3, 10 and 29 were built using different increments of the transmembrane potential. The pulse energy efficiency was evaluated according to their threshold energy ratios in mA2∙ms/cm4. There was virtually no difference between the threshold energy ratios of the three waveforms constructed and those of the previously studied energy-optimal half-sine waveform: 241 - 242 and 243 mA2∙ms/cm4. The pulse waveform constructed is characterized by a low rise and fall as the duration of the rise is ...
Vyacheslav A. Vostrikov, Boris B. Gorbunov, Sergey V. Selishchev
Energy-Optimal Defibrillation Pulse Waveform, Monophasic Defibrillation Pulse Waveforms, Modeling, Energy Ratio, Cardiomyocyte, Transmembrane Potential, Action Potential
Adobe PDF Library 11.0
"Energy-Optimal Defibrillation Pulse Waveform, Monophasic Defibrillation Pulse Waveforms, Modeling, Energy Ratio, Cardiomyocyte, Transmembrane Potential, Action Potential"
D:20150914061511
The goal is to help create smooth energy-optimal monophasic pulse waveforms for defibrillation using the Luo-Rudy cardiomyocyte membrane computer model. The waveforms were described with the help of the piecewise linear function. Each line segment provides a transition from one present level of the transmembrane potential to the next with a minimal energy value. The duration of the last segment was defined as a minimum duration at which an action potential occurs. Monophasic waveforms of segments 3, 10 and 29 were built using different increments of the transmembrane potential. The pulse energy efficiency was evaluated according to their threshold energy ratios in mA2â‹Žms/cm4. There was virtually no difference between the threshold energy ratios of the three waveforms constructed and those of the previously studied energy-optimal half-sine waveform: 241 - 242 and 243 mA2â‹Žms/cm4. The pulse waveform constructed is characterized by a low rise and fall as the duration of the rise is ~1.5 times longer than that of the fall. Conclusion: Energy-optimal smooth monophasic pulse waveforms have the same threshold energy ratio as the optimal half-sine one which was studied before. The latter is equivalent to the first phase of biphasic quasi-sinusoidal Gurvich-Venin pulse which has been used in Russia since 1972. Thus, the use of the Luo-Rudy cardiomyocyte membrane model appears to offer no possibilities for a substantial increase in the energy efficiency (threshold energy ratio reduction) of the classical monophasic defibrillation pulse waveforms.
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